Resumen
Wearable biosensors are revolutionizing medical diagnostics and continuous health monitoring by shifting the paradigm from
centralized care systems to personalized, home-based healthcare. This transition promises to enable precise clinical
decisions and enhance overall health outcomes while optimizing resource allocation. Leveraging our expertise in
biofunctionalization, biosensing, and transduction, we aim to develop hydrogel-based wearable optical biosensors (HWOB).
The sensing mechanism relies on creating slide-ring hydrogels combined with probes that undergo a substantial volume
change upon recognition events. This process will consequently lead to different diffractive properties, enabling highly
sensitive detection. These innovative sensors are designed for sweat and interstitial fluid sampling and their automated
miniaturized analysis. By integrating microneedles, hydrogel-based support, specific reagents, holographic techniques, and
optical detection, we aim to create a cohesive and reliable solution materialized in skin patch biosensors.
This ambitious project envisions three pivotal scenarios where innovative biosensors can profoundly improve current
methodologies. Our focus spans monitoring biomarkers associated with inflammatory bowel diseases, facilitating drug
allergy tests, and demonstrating unobtrusive detection of circulating biomarkers. Developing these wearable biosensors has
a relevant impact on redefining healthcare approaches, enhancing diagnostic precision, and fostering a more efficient and
proactive healthcare system.
