New approach for phylogenetic tree recovery based on genome-scale metabolic networks
Autores UPV | Urchueguía Schölzel Javier Fermín, Montagud Aquino Arnau, Gamermann Daniel, Fernández de Córdoba Castellá Pedro José, Conejero Casares José Alberto |
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Año | 2014 |
Revista | Journal of Computational Biology |
Abstract
A wide range of applications and research has been done with genome-scale metabolic models. In this work, we describe an innovative methodology for comparing metabolic networks constructed from genome-scale metabolic models and how to apply this comparison in order to infer evolutionary distances between different organisms. Our methodology allows a quantification of the metabolic differences between different species from a broad range of families and even kingdoms. This quantification is then applied in order to reconstruct phylogenetic trees for sets of various organisms.