Abstract
We report herein the design of a smart delivery system in
which cargo delivery from capped mesoporous silica (MS) nanoparticles is
controlled by an integrated enzyme-based control unit. The system consists
of Janus-type nanoparticles having opposing Au and MS faces, functionalized
with a pH-responsive β-cyclodextrin-based supramolecular nanovalve on the
MS surface and two effectors, glucose oxidase and esterase, immobilized on
the Au face. The nanodevice behaves as an enzymatic logical OR operator
which is selectively fueled by the presence of D-glucose and ethyl butyrate.
