Abstract
Multisite organicinorganic hybrid catalysts have
been prepared and applied in a new general, practical, and
sustainable synthetic procedure toward industrially relevant
GABA derivatives. The domino sequence is composed of seven
chemical transformations which are performed in two one-pot
reactions. The method produces both enantiomeric forms of
the product in high enantiopurity as well as the racemate in
good yields after a single column purification step. This
protocol highlights major process intensification, catalyst
recyclability, and low waste generation.
