Toxicity evaluation of functionalized mesoporous silica nanoparticles in C. elegans as in vivo model

Autores UPV
Año
CONGRESO Toxicity evaluation of functionalized mesoporous silica nanoparticles in C. elegans as in vivo model

Abstract

Among new materials for nanoencapsulating, Mesoporous Silica Nanoparticles (MSN) have a better stability of the structure and better capability to protect the cargo (Bernardos, 2008). However, the reactivity, bioavailability and toxicity of MSP materials still unknown. This study wants to know the real opportunities for nanomaterials applications based on silica mesoporous and its facilities to throw back the possible toxic effects.In order to carry out a toxicological evaluation, the nematode Carnorhabditis elegans have been selected as in vivo screening model. Toxicology evaluation was addressed by life cycle for a maximum period of 21 days. Nanoparticles were seeded on the agar plates for nematodes ingestion and the assays were evaluated with 5 ugml-1 of MSN.This study allows us to identify surface features of nanomaterials as an important route through which could be possible reduce the potential risk to introduce nanotechnology applications on devices for humans exposure.