PHOTOACTIVE PROBES AND THEIR INTERACTION WITH PROTEINS

Autores UPV
Año
CONGRESO PHOTOACTIVE PROBES AND THEIR INTERACTION WITH PROTEINS

Abstract

Chlorpromazine (CPZ), cyamemazine (CMZ), and carprofen methyl ester (CPM) are drug derivatives whose absorption spectra reach the UVB-UVA region; for that reason, they are potential photosensitizing agents. After irradiation, the singlet and triplet excited states of CMZ, CPZ and CPM are formed, together with other reactive species such as carbon-centered free radicals, reactive oxygen species, etc). In this context, a characterization of the photophysical and photochemical behavior of CPZ, CMZ and CPM within transport proteins (serum albumins and alfa-acid glycoproteins) has been performed, to investigate if the photogenerated intermediates can be responsible for biological damage